Sperm maturation arrest

Even in men with zero sperm in the ejaculate, and apparently no sperm production, if one looked carefully throughout the testicular specimens, an occasional sperm precursor could be found that had the same number of chromosomes and the same basic appearance as a normal sperm. Variability in the interpretation of testis histopathology must also be mentioned. In most of the men in our study the cause of infertility was idiopathic. Variability in testis biopsy interpretation: implications for male infertility care in the era of intracytoplasmic sperm injection. Cengiz Alatas. Compared to men with hypospermatogenesis who commonly have complete spermatogenesis in focal areas of the testes, men with late MA had increased testicular volume, decreased FSH and LH, increased genetic abnormalities and a decreased sperm retrieval rate, likely indicating incomplete spermatogenesis diffused throughout the testes. Y chromosome microdeletions were present in 8.

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Microscopic histologic description. Click here for information on linking to our website or using our content or images. Telephone: ; Email: CommentsPathout gmail. Cite this page: Al-Hussain T. A study done by Jungling and Bunge in had a small breakthrough in the field by orally distributing arginine, daily to a group of infertile men. Hidden categories: CS1 errors: missing periodical.

Sertoli cells. Cite this page: Al-Hussain T. Heat may also be the cause of oligozoospermia which can lead to both partial and reversible spermatogenic arrest. Complete maturation arrest : germ cell maturity ceases at a specific point frequently at primary spermatocyte level; sperm counts usually zero Incomplete maturation arrest : similar to complete but a few late spermatids are present in a few seminiferous tubules, some prefer the term hypospermatogenesis instead of incomplete maturation arrest Arch Pathol Lab Med ; ; patients are usually oligospermic Same etiologies as hypospermatogenesis diabetes mellitus, toxins, excess heat, varicocele, hypothyroidism, irradiation ; also postpubertal gonadotropin deficiency, alkylating agents Nonzero sperm counts indicate late spermatids are present somewhere in testis, although perhaps not in area biopsied Patients with early maturation arrest have a greater incidence of genetic anomalies and are more likely to have worse reproductive outcomes than are patients with late maturation arrest Urology ;